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  • 86639-52-3_7-Ethyl-10-hydroxycamptothecin(SN-38)

    Product Name: 7-Ethyl-10-hydroxycamptothecin
    CAS No.: 86639-52-3
    Synonyms: 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7] indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;
    7-ETHYL-10-HYDROXYCAMPTOTHECIN;
    7-ETHYL-10-HYDROXYCAMPTOTHECINE;
    7-ETHYL-10-HYDROXY-CPT;
    CAMPTOTHECIN, 7-ETHYL-10-HYDROXY;
    SN38
    Formula: C22H20N2O5
    Formula Weight: 392.4
    Appearance: Pale yellow crystalline powder
    Structure: structue of 7-Ethyl-10-hydroxycamptothecin sn38 CAS NO.:86639-52-3.
    Assay: min. 99.0%
    Storage Store at +4°C
    Melting point: 217 °C
    Flash Point: 443.8oC
    Density: 1.51 g/cm3
    efractive index: 21.5 ° (C=0.2, THF)
    Safety Information
    Safty Description: 45
    Hazard Statements: T
    Hazard Statements: H301+H311+H331-H301
    RTECS: UQ0491000
    HS Code: 29399900
    Packing & Storage: Packing with IATA required carton with 5kg/carton, or as customer required.
    Stored in a cool, dry and dark place, shelf life 24 months.

    Function:
    7-Ethyl-10-Hydroxycamptothecin showed remarkable anticancer activity in preliminary clinical trials by inhibiting the DNA enzyme topoisomerase I (topo I).

    Application:
    1. 7-Ethyl-10-Hydroxycamptothecin is the natural starting material of Irinotecan HCl.
    2. This compound 7-Ethyl-10-hydroxycamptothecin is a featured product for Apoptosis research.

    Natural origins of camptothecin:
    1. Camptotheca acuminata (Camptotheca, Happy tree), a tree native to Hunan ,Guangxi, Sichuan province of China. Camptotheca acuminata used as a cancer treatment in Traditional Chinese Medicine.Generally, the leaves and the fruits of happy tree are applied for the extraction of camptothecin.
    2. Nothapodytes pittosporoides(Mappia), a tree wild spread in Hunan ,Guangxi, Sichuan province of China. The root of the tree is applied for the extraction of campothecin, most of this origin is applied for R&D.

    Get in touch with us for premium 7-Ethyl-10-hydroxycamptothecin(SN-38)(cas number:186639-52-3)! We are a reliable Manufacturer, Supplier and Exporter of 7-Ethyl-10-hydroxycamptothecin(SN-38)(cas number:186639-52-3). The product is widely used as a metabolite of Irinotecan, a DNA topoisomerase inhibitor. Buyers are free to place orders of the product with us and we ensure the quality.
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