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  • Camptothecin_7689-03-4

    Product Name: Camptothecin
    CAS No.: 7689-03-4
    MDL Number: MFCD00081076
    Jingyu Number: C1
    Chemical name: (S)-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline -3,14(4H,12H)-dione
    Formal Name: (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
    Formula: C20H16N2O4
    Formula Weight: 348.35
    Appearance: Pale yellow needle crystalline powder
    Structure: structue of Camptothecin cas number is 7689-03-4
    Assay: min. 99.0%
    Melting point: 260 °C (dec.)(lit.)
    Water Solubility: insoluble
    Smiles: O=C([C@@]1(CC)O)OCC2=C1C=C(C(N=C(C=CC=C3)C3=C4)=C4C5)N5C2=O
    Stability: ≥ 2 years
    Solubility: Clear Yellow Solution at 1Mg/Ml in Dimethylsulfoxide
    Handling Protect from light and moisture
    Storage: Store in a cool and dry area. Keep sealed and keep away from direct light.
    Safety Information of Camptothecin (cas number:7689-03-4) as below:
    Hazard Codes: T,Xi,Xn
    Risk Statements: 36/37/38-25-20/21/22
    Safety Statements: 45-36/37/39-26-36
    RIDADR: UN 1544 6.1/PG 3
    WGK Germany: 3
    RTECS: UQ0492000
    Hazard Note: Irritant
    HazardClass: 6.1
    PackingGroup:

    Application:
    1. Camptothecin is the natural starting material of Irinotecan HCl.
    2. Camptothecin is the natural starting compound of 10-Hydroxycamptothecin.
    3. Camptothecin is the natural starting ingredient of 7-Ethyl-10-Hydroxycamptothecin(SN-38).
    4. Camptothecin is the natural starting ingredient of Topotecan HCl
    5. This compound camptothecin is a featured product for Apoptosis research.

    Packing & Storage
    Packing with IATA required carton with 10kg/carton, or as customer required.
    Stored in a cool, dry and dark place, shelf life 24 months.

    Function:
    Camptothecin showed remarkable anticancer activity in preliminary clinical trials by inhibiting the DNA enzyme topoisomerase I (topo I). (S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.

    Natural origins of camptothecin:
    1. Camptotheca acuminata (Camptotheca, Happy tree), a tree native to Hunan ,Guangxi, Sichuan province of China. Camptotheca acuminata used as a cancer treatment in Traditional Chinese Medicine.Generally, the leaves and the fruits of happy tree are applied for the extraction of camptothecin.
    2. Nothapodytes pittosporoides(Mappia), a tree wild spread in Hunan ,Guangxi, Sichuan province of China. The root of the tree is applied for the extraction of campothecin, most of this origin is applied for R&D.

    Get in touch with us for premium Camptothecin (cas number:7689-03-4)! We are a reliable Manufacturer, Supplier and Exporter of Camptothecin (cas number:7689-03-4). The product is widely used as Antitumor alkaloid. Buyers are free to place orders of the product with us and we ensure the quality.
    downstream product 10-Hydroxycamptothecin
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